Iakushev V S, Lifshits R I, Slobodin V B, Kamilov F Kh, Efimenko G P
Kardiologiia. 1975 Apr;15(4):114-8.
The effect of trasylol upon the activeness of proteolysis in the cytoplasm and mitochondrial-lysosomal fractions of the heart muscle was studied in the acute experimental period of myocardial ischaemia (5 days) along with a determination of the spectrum of the iso-enzymes of the lactate- and malate- dehydrogenases. For the evaluation of oxidation processes in vitro the iections. Trasylol was found to limit the proteolysis in the cytostructures of the myocardium cell, to increase the activity of the transaminases, as well as to help the normalization of thespectrum of the NAD-dependent iso-enzymes. At the same time, under the effect of the employed drug, the myocardial consumption of the radioactive carbon from the acetate Na-2C-14 increases.
在心肌缺血的急性实验期（5天），研究了抑肽酶对心肌细胞质和线粒体 - 溶酶体部分蛋白水解活性的影响，并测定了乳酸脱氢酶和苹果酸脱氢酶同工酶谱。为了评估体外氧化过程进行了注射。发现抑肽酶可限制心肌细胞胞质结构中的蛋白水解，增加转氨酶的活性，并有助于NAD依赖同工酶谱的正常化。同时，在所使用药物的作用下，心肌对来自醋酸钠 - 2C - 14的放射性碳的消耗量增加。
