Usatenko M S
Biokhimiia. 1977 Feb;42(2):311-9.
A correlation is shown to exist between malate dehydrogenase (MDH), lactate dehydrogenase (LDH) and glycerol-3-phosphate dehydrogenase (glycerol-3-PDH activity values, lactate/pyruvate and malate/oxaloacetate coefficients, MDH and LDH isozyme spectra and kinetic properties of LDH isozymes in soluble fractions of cytoplasm from intact rabbit m. soleus (red), m. gastrocnemius (mixed) and m. quadratus lumborum (white). In denervated soleus and gastrocnemius the cytoplasmic MDH/LDH, mitochondrial MDH/LDH, MDH mitochondrial/MDH cytoplasmic activity ratios, concentrations of substrates and isozyme spectra of MDH and LDH tend to equalize. The obtained results indicate the importance of isozyme composition and total activity ratios of the dehydrogenases for regulation of pyruvate and NADH metabolic pathways.
在完整的兔比目鱼肌（红色）、腓肠肌（混合性）和腰大肌（白色）细胞质可溶部分中，苹果酸脱氢酶（MDH）、乳酸脱氢酶（LDH）和甘油 - 3 - 磷酸脱氢酶（甘油 - 3 - PDH）的活性值、乳酸/丙酮酸和苹果酸/草酰乙酸系数、MDH和LDH同工酶谱以及LDH同工酶的动力学特性之间显示出相关性。在去神经支配的比目鱼肌和腓肠肌中，细胞质MDH/LDH、线粒体MDH/LDH、MDH线粒体/MDH细胞质活性比率、底物浓度以及MDH和LDH的同工酶谱趋于平衡。所得结果表明脱氢酶的同工酶组成和总活性比率对丙酮酸和NADH代谢途径调节的重要性。
