Hedner U, Henriksson P, Nilsson I M
Scand J Haematol. 1975 Apr;14(2):114-9. doi: 10.1111/j.1600-0609.1975.tb00303.x.
In 339 patients with various diseases factor XIII (FSF) was determined with the specific amine incorporation method of Lorand et al (1969). Normal values were found in patients with renal (216 patients) or liver diseases (33 patients), in 39 patients with recurrent deep venous thrombosis and in 17 children with congenital cyanotic heart disease. Low levels were found in patients with various conditions, such as sepsis, multiple fractures and combustio complicated by an abnormal proteolytic activity (fibrinolysis and/or activation of the coagulation system with signs of disseminated coagulation). No correlation was found between the FSF and the fibrinogen values or the levels of fibrin/fibrinogen degradation products (FDP). Low FSF values were found in 4 patients with erosive gastritis, with gastrointestinal bleedings and a local fibrinolytic activity in the gastric juice. Although the FSF must be very low (smaller than 1%) if it is to cause bleedings, the low levels in these patients with many other coexisting disturbances in the coagulation system and/or an increased fibrinolytic activity most probably contribute to the increased bleeding tendency in such patients.
采用洛兰德等人（1969年）的特定胺掺入法，对339例患有各种疾病的患者进行了凝血因子 XIII（FSF）测定。在患有肾脏疾病（216例患者）或肝脏疾病（33例患者）、39例复发性深静脉血栓形成患者以及17例先天性青紫型心脏病患儿中，均发现FSF值正常。在患有各种病症的患者中发现FSF水平较低，例如败血症、多发性骨折以及伴有异常蛋白水解活性（纤维蛋白溶解和/或凝血系统激活并伴有弥散性凝血迹象）的烧伤。未发现FSF与纤维蛋白原值或纤维蛋白/纤维蛋白原降解产物（FDP）水平之间存在相关性。在4例患有糜烂性胃炎、伴有胃肠道出血且胃液中有局部纤维蛋白溶解活性的患者中发现FSF值较低。尽管FSF要导致出血必须非常低（小于1%），但在这些同时存在许多其他凝血系统紊乱和/或纤维蛋白溶解活性增加的患者中，FSF水平较低很可能导致此类患者出血倾向增加。
