Al-Majali A M, Asem E K, Lamar C H, Robinson J P, Freeman M J, Saeed A M
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
FEMS Immunol Med Microbiol. 2000 Jun;28(2):97-104. doi: 10.1111/j.1574-695X.2000.tb01462.x.
Enterotoxigenic Escherichia coli (ETEC) induces severe diarrhea in newborn calves through the elaboration of heat-stable enterotoxin (STa). We investigated the distribution and characteristics of the STa-specific receptors on enterocytes and brush border membrane vesicles (BBMVs) prepared from anterior jejunum, posterior jejunum, ileum and colon of newborn calves. We found that density of the receptors and their affinity to STa were higher on enterocytes and BBMVs that were derived from the ileum than enterocytes and BBMVs prepared from other segments of the calf intestine. This study suggests that, in newborn calves, the ileum is the major part of the intestinal tract that is affected in the course of secretory diarrhea caused by STa-producing ETEC strains.
产肠毒素大肠杆菌（ETEC）通过产生热稳定肠毒素（STa）在新生犊牛中引发严重腹泻。我们研究了新生犊牛空肠前段、空肠后段、回肠和结肠制备的肠上皮细胞和刷状缘膜囊泡（BBMVs）上STa特异性受体的分布和特征。我们发现，回肠来源的肠上皮细胞和BBMVs上的受体密度及其对STa的亲和力高于犊牛肠道其他节段制备的肠上皮细胞和BBMVs。本研究表明，在新生犊牛中，回肠是产STa的ETEC菌株引起的分泌性腹泻过程中受影响的主要肠道部位。
