Essig M, Bock M
Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Magn Reson Med. 2000 May;43(5):764-7. doi: 10.1002/(SICI)1522-2594(200005)43:5<764::AID-MRM21>3.0.CO;2-F.
After surgical resection of a brain tumor or infection of the cerebrospinal fluid (CSF), elevated levels of blood by-products or protein contaminations are seen in the patient's CSF spaces. In fast fluid-attenuated inversion-recovery (FLAIR) imaging CSF signal is nulled by an appropriate choice of the inversion recovery time TI to improve the contrast between tissue structures adjacent to CSF-filled volumes. With contaminated CSF, however, the longitudinal relaxation time T(1) may change significantly, which results in an incomplete suppression in the FLAIR images, if standard inversion times are used. In this work, a fast single-voxel T(1) measurement pulse sequence with integrated T(1) calculation that allows determination the optimal TI value in 15 sec is presented. The method was tested in five patients after surgical resection of a brain tumor, where FLAIR MRI with and without contrast agent was performed to identify remaining tumor fragments at the margin of the resection cavity.
在脑肿瘤手术切除或脑脊液（CSF）感染后，患者的脑脊液间隙中会出现血液副产物或蛋白质污染水平升高的情况。在快速液体衰减反转恢复（FLAIR）成像中，通过适当选择反转恢复时间TI使脑脊液信号无效，以提高与充满脑脊液的区域相邻的组织结构之间的对比度。然而，对于受污染的脑脊液，纵向弛豫时间T(1)可能会发生显著变化，如果使用标准反转时间，这会导致FLAIR图像中抑制不完全。在这项工作中，提出了一种具有集成T(1)计算功能的快速单体素T(1)测量脉冲序列，该序列能够在15秒内确定最佳TI值。该方法在5例脑肿瘤手术切除后的患者中进行了测试，通过有无造影剂的FLAIR MRI来识别切除腔边缘残留的肿瘤碎片。
