Buéno L, Fioramonti J, Garcia-Villar R
Institut National de la Recherche Agronomique, Neuro-Gastroenterology & Nutrition Unit, 31931 Toulouse, France.
Am J Physiol Gastrointest Liver Physiol. 2000 May;278(5):G670-6. doi: 10.1152/ajpgi.2000.278.5.G670.
Visceral pain is the major cause of consulting in gastroenterology and the principal symptom of functional bowel disorders. This symptom is often associated with gut hypersensitivity to distension. The use of animal models has recently permitted the identification of some mediators supposed to play a pivotal role in the genesis of visceral hypersensitivity. Serotonin, through different receptor subtypes, as well as kinins and calcitonin gene-related peptide, are known to be involved, but other putative transmitters arise and are new potential targets for the development of efficacious treatments. This themes article addresses both physiological and preclinical issues of interest for the selection of active new drugs in regard to the clinical pharmacology of visceral pain.
内脏痛是胃肠病学中患者就诊的主要原因以及功能性肠病的主要症状。这种症状常与肠道对扩张的超敏反应相关。最近，动物模型的应用使得一些被认为在内脏超敏反应发生过程中起关键作用的介质得以鉴定。已知血清素通过不同的受体亚型以及激肽和降钙素基因相关肽参与其中，但其他假定的递质也逐渐出现，成为开发有效治疗方法的新潜在靶点。这篇主题文章探讨了在内脏痛临床药理学方面选择活性新药时所涉及的生理学和临床前问题。
