Collins S
Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Gut. 2004 Mar;53 Suppl 2(Suppl 2):ii19-21. doi: 10.1136/gut.2003.033456.
The management of abdominal pain remains a major challenge for clinicians despite an explosion of knowledge regarding the physiology and pathophysiology of sensory neural circuits. Initial progress was made in the field of somatic pain and this provided broad hypotheses that could be tested in the field of visceral pain. The major advances in our understanding of basic mechanisms underlying visceral pain originated in the urinary tract and have been applied to the gut. As yet, this increased understanding of enteric sensory physiology has yet to generate new effective treatments for abdominal pain. This review addresses novel insights into peripheral mechanisms underlying visceral hyperalgesia and their applicability to the development of novel therapeutic approaches to the treatment of chronic abdominal pain.
尽管在感觉神经回路的生理学和病理生理学方面知识激增，但腹痛的管理对临床医生来说仍然是一项重大挑战。躯体痛领域取得了初步进展，这提供了可在内脏痛领域进行检验的广泛假设。我们对内脏痛基本机制的理解取得的主要进展源自泌尿道，并已应用于肠道。然而，对肠道感觉生理学的这种深入理解尚未产生治疗腹痛的新的有效疗法。本综述阐述了对内脏痛觉过敏外周机制的新见解及其在开发慢性腹痛新治疗方法中的适用性。
