膜细胞骨架：磷脂酰肌醇-4,5-二磷酸（PIP(2)）操控一切。

Membrane cytoskeleton: PIP(2) pulls the strings.

作者信息

Nebl T, Oh S W, Luna E J

机构信息

Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01605, USA.

出版信息

Curr Biol. 2000 May 4;10(9):R351-4. doi: 10.1016/s0960-9822(00)00465-6.

DOI:10.1016/s0960-9822(00)00465-6

PMID:10801429

Abstract

A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.

摘要

光镊技术最近的一项应用表明，质膜磷脂酰肌醇4,5 - 二磷酸（PIP(2)）水平通过PIP(2)与细胞骨架蛋白的调控直接结合和/或对细胞骨架结构的间接影响，来控制膜双层与下层细胞骨架的粘附。