转录调控：自杀式激活因子
Transcriptional regulation: Kamikaze activators.
作者信息
Thomas D, Tyers M
机构信息
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvettte, 91198, France.
出版信息
Curr Biol. 2000 May 4;10(9):R341-3. doi: 10.1016/s0960-9822(00)00462-0.
Abstract
Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.
摘要
转录因子常常是泛素-蛋白酶体系统快速降解的作用靶点。最近的证据表明转录激活因子的活性与其不稳定性之间存在关联，这表明泛素依赖性蛋白水解在转录激活过程中可能具有直接作用。
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