Coudray C, Tressol J C, Feillet-Coudray C, Bellanger J, Pépin D, Mazur A
Centre de Recherche en Nutrition Humaine d'Auvergne, Laboratoire Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix, 63122 Saint Genès Champanelle, France.
J Nutr. 2000 May;130(5):1309-13. doi: 10.1093/jn/130.5.1309.
Red wines contain many components such as polyphenols and ethanol that may influence mineral absorption. We report on studies in a rat model that were designed to investigate the extent to which short- and long-term intake of red wine or ethanol may influence (67)Zn and (65)Cu absorption in rats. Rats (n = 96) were divided into three groups, a control group that received demineralized water, a group that received red wine diluted with water (v/v) and an ethanol group that received 6% ethanol. Half of each group was used for the short-term study; the others were used for the long-term study. After 3 d (short-term study) or 28 d (long-term study) of beverage consumption, the rats were gavaged with 2 mL of solution containing 2027 nmol (67)Zn and 902 nmol (65)Cu. Subsequently, 3-d urinary and fecal collections were performed and analyzed for total and isotopic Zn and Cu. In the long-term study, blood, tibia and liver were also sampled for mineral status assessment. Neither short- nor long-term intake of red wine altered (67)Zn or (65)Cu absorption. In contrast, long-term (but not short-term) ethanol consumption significantly increased both (67)Zn and (65)Cu absorption compared with the control and red wine groups. The long-term consumption of ethanol or red wine did not affect blood or tissue Zn or Cu levels. In conclusion, short- or long-term consumption of red wine did not have a negative effect on intestinal absorption or tissue levels of zinc and Cu in rats.
红酒含有许多成分，如多酚和乙醇，这些成分可能会影响矿物质吸收。我们报告了在大鼠模型中进行的研究，这些研究旨在调查短期和长期摄入红酒或乙醇对大鼠（67）锌和（65）铜吸收的影响程度。大鼠（n = 96）被分为三组，一组为接受去离子水的对照组，一组为接受用水稀释的红酒（体积比）的组，还有一组为接受6%乙醇的乙醇组。每组的一半用于短期研究；另一半用于长期研究。在饮用饮料3天（短期研究）或28天（长期研究）后，给大鼠灌胃2 mL含有2027 nmol（67）锌和902 nmol（65）铜的溶液。随后，进行3天的尿液和粪便收集，并分析总锌和铜以及同位素锌和铜。在长期研究中，还采集血液、胫骨和肝脏样本以评估矿物质状态。短期和长期摄入红酒均未改变（67）锌或（65）铜的吸收。相比之下，与对照组和红酒组相比，长期（而非短期）摄入乙醇显著增加了（67）锌和（65）铜的吸收。长期摄入乙醇或红酒并未影响血液或组织中的锌或铜水平。总之，短期或长期饮用红酒对大鼠肠道对锌和铜的吸收或组织水平没有负面影响。
