Björk P, Knöös T, Nilsson P, Larsson K
Department of Radiation Physics, Lund University Hospital, Lund, Sweden.
Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):527-33. doi: 10.1016/s0360-3016(00)00456-9.
The design concept and the dosimetric characteristics of an applicator system for intraoperative radiation therapy (IORT) with special emphasis on alignment methods, the effect of a plastic scatterer in the beam, radiation leakage, and misalignment dosimetry, are presented in this paper.
A soft-docking system for a linear accelerator, which enables collimation of electron beams (4-22 MeV) for IORT has been developed. The system includes twenty-one circular polymethylmethacrylate (PMMA) treatment cones of different lengths, diameters and end angles. All in-water measurements are made using p-type silicon diode detectors.
The effect of introducing a PMMA scatterer in the therapeutic beam includes increased surface dose values (above 83% for all nominal electron energies and for all cones) and improved dose homogeneity within the therapeutic range. Electrons scattered from the inside wall of the cone result in dose profile horns at depth of dose maximum always lower than 109%. The radiation leakage outside the cone is less than 13%. Large changes in the dose profiles occur if the intraoperative cone is misaligned more than 0.5.
The alignment procedure of the soft-docking system is easy to handle and the applicator design provides adequate collimation of electron beams for IORT.
本文介绍了一种术中放射治疗(IORT)施源器系统的设计理念和剂量学特性,特别强调了对准方法、束流中塑料散射体的影响、辐射泄漏和对准误差剂量学。
已开发出一种用于直线加速器的软对接系统,该系统可实现用于IORT的电子束(4 - 22 MeV)的准直。该系统包括21个不同长度、直径和端角的圆形聚甲基丙烯酸甲酯(PMMA)治疗锥。所有水中测量均使用p型硅二极管探测器进行。
在治疗束中引入PMMA散射体的效果包括表面剂量值增加(对于所有标称电子能量和所有锥体,均高于83%)以及治疗范围内剂量均匀性得到改善。从锥体内壁散射的电子在剂量最大值深度处导致剂量分布角始终低于109%。锥体外部的辐射泄漏小于13%。如果术中锥体对准误差超过0.5,则剂量分布会发生较大变化。
软对接系统的对准程序易于操作,并且施源器设计为IORT提供了足够的电子束准直。