头孢噻肟相关的过敏性间质性肾炎和髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）阳性血管炎。

Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis.

作者信息

Feriozzi S, Muda A O, Gomes V, Montanaro M, Faraggiana T, Ancarani E

机构信息

Nefrologia e Dialisi, Ospedale Belcolle, Viterbo, Italy.

出版信息

Ren Fail. 2000 Mar;22(2):245-51. doi: 10.1081/jdi-100100869.

DOI:10.1081/jdi-100100869

PMID:10803769

Abstract

We report a case of reversible acute renal failure after cefotaxime treatment in a patient affected by non-Hodgkin lymphoma. Renal biopsy showed necrotizing vasculitis associated with eosinophil-rich interstitial inflammatory infiltrates and patchy infiltrates of CD20+ lymphoid cells. High serum p-ANCA titers were also detected. Drug withdrawal was closely related with recovery of renal function and disappearance of ANCA. Acute renal failure therefore represented a consequence of ANCA-mediated renal vasculitis and acute interstitial nephritis related to cefotaxime treatment.

摘要

我们报告了一例非霍奇金淋巴瘤患者在接受头孢噻肟治疗后出现可逆性急性肾衰竭的病例。肾活检显示坏死性血管炎，伴有富含嗜酸性粒细胞的间质炎性浸润以及CD20+淋巴细胞的斑片状浸润。还检测到高血清p-ANCA滴度。停药与肾功能恢复及ANCA消失密切相关。因此，急性肾衰竭是ANCA介导的肾血管炎和与头孢噻肟治疗相关的急性间质性肾炎的结果。