一种常见药物的罕见不良反应：呋喃妥因诱发的抗中性粒细胞胞浆抗体相关性血管炎。
Rare adverse effect of a common drug: nitrofurantoin-induced ANCA-associated vasculitis.
作者信息
Agarwal Abhishek, Agrawal Abhinav, Nathan Karim, Roy Satyajeet
机构信息
Cooper University Hospital, Philadelphia, Pennsylvania, USA.
Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
出版信息
BMJ Case Rep. 2015 May 2;2015:bcr2014209253. doi: 10.1136/bcr-2014-209253.
Abstract
Nitrofurantoin is commonly prescribed to treat urinary tract infections (UTI). Reported adverse effects include gastrointestinal, pulmonary, hepatic and neurological disorders. We report a case of a 67-year-old woman treated for UTI with nitrofurantoin who presented with antineutrophilic cytoplasmic antibody (ANCA)-associated renal and skin vasculitis 3 days after starting treatment. The symptoms resolved following withdrawal of the drug and treatment with steroids. This is the first reported case of nitrofurantoin causing ANCA-associated vasculitis.
摘要
呋喃妥因常用于治疗尿路感染（UTI）。报告的不良反应包括胃肠道、肺部、肝脏和神经系统疾病。我们报告一例67岁女性，因UTI接受呋喃妥因治疗，在开始治疗3天后出现抗中性粒细胞胞浆抗体（ANCA）相关的肾和皮肤血管炎。停药并使用类固醇治疗后症状缓解。这是首例报告的呋喃妥因引起ANCA相关血管炎的病例。
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