Biering H, Knappe G, Gerl H, Lochs H
Medizinischen Klinik mit Schwerpunkt Gastroenterologie, Hepatologie und Endokrinologie des Universitätsklinikums Charité, Berlin, Deutschland. Dr.
Acta Med Austriaca. 2000;27(1):27-31. doi: 10.1046/j.1563-2571.2000.200106.x.
In a retrospective study glucose metabolism was investigated in 206 patients with acromegaly and 131 patients with Cushing's disease. 40.5% of the patients with hypersomatotropism and 32.0% of the patients with hypercortisolism suffered from overt diabetes mellitus. Impaired glucose tolerance was present prior to therapy in 28.2% and 30.6% of the patients, respectively. In acromegaly the incidence of overt diabetes mellitus was higher in women than in men, but no difference existed in the distribution of impaired glucose tolerance between both sexes. No correlation was found between growth hormone levels and occurrence of diabetes. In acromegaly and Cushing's disease overt diabetes increased with advanced age. Diabetes mellitus occurred independently from the etiology of hypercortisolism.
在一项回顾性研究中，对206例肢端肥大症患者和131例库欣病患者的糖代谢情况进行了调查。40.5%的生长激素过多患者和32.0%的皮质醇过多患者患有显性糖尿病。分别有28.2%和30.6%的患者在治疗前存在糖耐量受损。在肢端肥大症中，显性糖尿病的发病率女性高于男性，但两性之间糖耐量受损的分布没有差异。未发现生长激素水平与糖尿病的发生之间存在相关性。在肢端肥大症和库欣病中，显性糖尿病的发病率随年龄增长而增加。糖尿病的发生与皮质醇过多的病因无关。
