Triggle D J
Graduate School, State University of New York, Buffalo 14260, USA.
Pharm Acta Helv. 2000 Mar;74(2-3):79-84. doi: 10.1016/s0031-6865(99)00046-1.
A brief survey of the history of the development of the concept of the pharmacological receptor is presented. From the pioneering concepts of Paul Ehrlich, John Langley and others, receptors are described in terms of their recognition properties, their structures, transducing abilities and the impact of genomics and their role in contributing to genetic diseases. The receptor concept has firmly underpinned our advances in drug development and molecular medicine of the latter half of this century and it is clear that it will continue to drive pharmaceutical developments in the 21st century.
本文简要回顾了药理学受体概念的发展历程。从保罗·埃尔利希、约翰·兰利等人的开创性概念开始，受体从其识别特性、结构、转导能力以及基因组学的影响和在导致遗传疾病中的作用等方面进行了描述。受体概念为本世纪后半叶我们在药物开发和分子医学方面的进展奠定了坚实基础，显然它将继续推动21世纪的药物研发。
