药物受体理论的出现。

The emergence of the drug receptor theory.

作者信息

Maehle Andreas-Holger, Prüll Cay-Rüdiger, Halliwell Robert F

机构信息

Centre for History of Medicine and Disease, Wolfson Research Institute, University of Durham, Queen's Campus, Stockton, University Boulevard, Stockton-on-Tees TS17 6BH, UK.

出版信息

Nat Rev Drug Discov. 2002 Aug;1(8):637-41. doi: 10.1038/nrd875.

DOI:10.1038/nrd875

PMID:12402503

Abstract

Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most important observations, and those of Paul Ehrlich and Alfred Joseph Clark, who similarly helped to establish the receptor theory of drug action.

摘要

如今，药物和递质特异性受体的概念是药理学的核心所在。不到一百年前，这一全新理念在科学界遭遇了相当大的阻力。为纪念受体概念的奠基人之一约翰·纽波特·兰利诞辰150周年，我们着重介绍他最重要的发现，以及保罗·埃尔利希和阿尔弗雷德·约瑟夫·克拉克的发现，他们同样为确立药物作用的受体理论做出了贡献。