Bravi C M, Bailliet G, Martinez-Marignac V L, Bianchi N O
Multidisciplinary Institute of Cell Biology (IMBICE), 1900 La Plata, Argentina.
Am J Phys Anthropol. 2000 Jun;112(2):149-58. doi: 10.1002/(SICI)1096-8644(2000)112:2<149::AID-AJPA2>3.0.CO;2-M.
We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP+ chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP+ chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP+ lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP+ lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAP+ elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models.
我们筛查了总共841条Y染色体，这些Y染色体代表了广泛地理分布的36个人类群体，以检测Y特异性Alu插入序列（YAP+染色体）的存在。在77个样本中发现了Alu元件。我们在77条YAP+染色体中的70条上检测了5个双等位基因标记和8个多等位基因标记。我们能够识别出祖先和衍生YAP+谱系的分层和时间结构的存在，产生了4个单倍群、14个亚单倍群和60个单倍型。此外，我们为每个YAP+谱系提出了单系起源。已经提出了非洲外和亚洲外模型来解释祖先和衍生YAP+元件的起源和进化。我们分析了支持这两种假设的证据，并得出结论，现有信息无法让人在亚洲外或非洲外模型之间做出决定。
