Shaw M M, Miller J D, Steven J L
J Neurol Neurosurg Psychiatry. 1975 Oct;38(10):1022-6. doi: 10.1136/jnnp.38.10.1022.
Intraventricular pressure was studied in 12 patients undergoing ventriculography with a water soluble positive contrast medium. Isovolumetric instillation of meglumine iothalamate into the lateral ventricles and the anterior part of the third ventricle caused only a small increase in ventricular fluid pressure (1.3 +/- 0.3 mmHg), but the pressure increased markedly (46.3 +/- 3.7 mmHg; P less than 0.001) when the contrast medium entered the posterior end of the third ventricle, aqueduct of Sylvius,, and fourth ventricle. This sharp increase in intracranial pressure could not be attributed solely to the postural changes or to alterations in arterial blood pressure. Possible mechanisms are discussed.
对12例使用水溶性阳性造影剂进行脑室造影的患者进行了脑室内压力研究。向侧脑室和第三脑室前部等容注入碘他拉葡胺仅使脑室液压力略有升高（1.3±0.3 mmHg），但当造影剂进入第三脑室后端、中脑导水管和第四脑室时，压力显著升高（46.3±3.7 mmHg；P<0.001）。颅内压的这种急剧升高不能仅归因于体位变化或动脉血压改变。文中讨论了可能的机制。
