Klee J G, Praestholm J
Invest Radiol. 1975 May-Jun;10(3):244-50. doi: 10.1097/00004424-197505000-00009.
Clinical, radiological and histopathological findings following cerebral ventriculography in the rat using the water-soluble contrast media iothalamate meglumine and metrizamide, and the oil-soluble iodophendylate are reported. Clinically, iothalamate meglumine caused convulsions, while there were no adverse reactions to the other media. Radiologically there was good visualizaiton of the ventricles with all media. Iodophendylate was retained in the ventricles for the duration of the experiment (up to 60 days), while the water-soluble media had disappeared within 20 minutes. Histologically there were no pathological changes attributable to the water-soluble media. Iodophendyalte led to enlargement of the ventricles, and macrophages containing oil were seen on the ependymal lining.
报告了在大鼠中使用水溶性造影剂葡甲胺碘肽和甲泛葡胺以及油溶性碘苯酯进行脑室造影后的临床、放射学和组织病理学结果。临床上，葡甲胺碘肽引起惊厥，而其他造影剂未出现不良反应。放射学上，所有造影剂均能良好显示脑室。在实验期间（长达60天）碘苯酯一直保留在脑室内，而水溶性造影剂在20分钟内就消失了。组织学上，未发现水溶性造影剂引起的病理变化。碘苯酯导致脑室扩大，在室管膜内衬上可见含油的巨噬细胞。
