Weems T D, Cashion E L, Cunningham D L
Neuroradiology. 1977 May 31;13(3):151-4. doi: 10.1007/BF00626277.
Meglumine iothalamate, an iodinated contrast agent, is commonly used in humans for roentgenographic outlining of cerebral ventricles. Although clinical studies have shown meglumine iothalamate to be less toxic than other radiopaque materials, its microscopic effects on brain tissue have never been studied in a controlled manner. For this study canine cerebral tissue was exposed to intraventricular saline or saline plus meglumine iothalamate and the results were compared by light microscopy. Reactive changes were found in both groups. They occurred with greater frequency and degree in the group exposed to meglumine iothalamate, but permanent damage to brain tissue, did not occur.
碘他拉葡胺，一种含碘造影剂，常用于人体脑室的X线造影。尽管临床研究表明碘他拉葡胺的毒性低于其他不透射线的物质，但其对脑组织的微观影响从未得到过对照研究。在本研究中，将犬脑组织暴露于脑室内生理盐水或生理盐水加碘他拉葡胺中，并通过光学显微镜比较结果。两组均发现有反应性变化。在暴露于碘他拉葡胺的组中，这些变化出现的频率和程度更高，但未发生对脑组织的永久性损伤。
