Bonnet F, Dequae-Merchadou L, Taupin J L, Sire S, Dupon M, Ragnaud J M, Lacoste D, Texier-Maugein J, Romagné F, Dabis F, Pellegrin J L, Moreau J F
Service de médecine interne et maladies infectieuses, Hôpital du Haut-Lévêque, CHU Bordeaux, France.
Microbes Infect. 1999 Aug;1(10):771-6. doi: 10.1016/s1286-4579(99)80079-3.
In a retrospective study, an increase in double-negative (CD3+ CD4- CD8-) (DN) T lymphocytes has been shown to be an independent predictor of disseminated Mycobacterium avium complex (D.MAC) infection in patients with less than 100 CD4+ T cells per mm3. To better characterize this cell expansion, a prospective study was designed. From July 1995 to April 1997, 206 HIV-infected patients with less than 100 CD4+ T cells per mm3 were prospectively followed up and immunophenotyped. The median followup was 1.1 year (+/-0.5 year), and 14 new D.MAC infections were diagnosed among 84 first AIDS-defining events. In univariate and multivariate analyses, D.MAC infections were the only opportunistic infection with a significant increase in DN T-cell percentage (median = 6.6; range = 1.7 to 24.5, P = 0.004) compared with patients without any opportunistic infection. This alteration in T-lymphocyte count could constitute a predictor for D.MAC infection in clinical practice.
在一项回顾性研究中，已表明双阴性（CD3+ CD4- CD8-）（DN）T淋巴细胞增加是每立方毫米CD4+ T细胞少于100个的患者发生播散性鸟分枝杆菌复合体（D.MAC）感染的独立预测指标。为了更好地描述这种细胞扩增情况，设计了一项前瞻性研究。1995年7月至1997年4月，对206例每立方毫米CD4+ T细胞少于100个的HIV感染患者进行了前瞻性随访和免疫表型分析。中位随访时间为1.1年（±0.5年），在84例首次出现艾滋病定义事件的患者中诊断出14例新的D.MAC感染。在单变量和多变量分析中，与无任何机会性感染的患者相比，D.MAC感染是唯一一种DN T细胞百分比显著增加的机会性感染（中位值 = 6.6；范围 = 1.7至24.5，P = 0.004）。T淋巴细胞计数的这种改变可能构成临床实践中D.MAC感染的一个预测指标。
