艾滋病患者的播散性鸟分枝杆菌复合群感染。附100例病例。阿基坦艾滋病临床流行病学组

[Disseminated Mycobacterium avium complex infections in AIDS. Apropos of 100 cases. Groupe d'Epidémiologie clinique du SIDA en Aquitaine].

作者信息

Lasseur C, Maugein J, Pellegrin J L, Dupon M, Ragnaud J M, Morlat P, Pellegrin I, Constans J, Monlun E, Chene G

机构信息

Groupe d'Epidémiologie clinique du sida en Aquitaine, Hôpital Haut-Lévêque, CHU Bordeaux, Pessac, France.

出版信息

Rev Med Interne. 1995;16(2):110-20. doi: 10.1016/0248-8663(96)80675-8.

DOI:10.1016/0248-8663(96)80675-8

PMID:7709100

Abstract

The improvement of survival of AIDS patients allowed the emergence of disseminated Mycobacterium avium Complex infections (D.MAC). Here we report the experience of the group of "Epidémiologie clinique du sida en Aquitaine (GECSA)" about 100 patients. There were no differences according to sex, age and route of acquisition of HIV. Clinical and biological characteristics of the infections were not specific. The mean TCD4+ lymphocytes count was 18/mm3. The diagnostic was generally established by systematic blood culture on Septi-Chek in patients with TCD4+ lymphocytes count below 75/mm3. The recommendations on therapy for D.MAC are to use regimen containing azithromycin or clarithromycin, ethambutol and one of the following drugs, rifabutin, clofazimine, amikacin, or ciprofloxacin. Rifabutin is recommended for prophylaxis in patients with lymphocytes TCD4+ count below 100/mm3.

摘要

艾滋病患者生存率的提高使得播散性鸟分枝杆菌复合体感染（D.MAC）出现。在此，我们报告“阿基坦地区艾滋病临床流行病学研究组（GECSA）”对100例患者的研究经验。在性别、年龄和HIV感染途径方面没有差异。感染的临床和生物学特征不具有特异性。TCD4 +淋巴细胞平均计数为18/mm³。对于TCD4 +淋巴细胞计数低于75/mm³的患者，诊断通常通过在Septi-Chek上进行系统性血培养来确立。关于D.MAC治疗的建议是使用包含阿奇霉素或克拉霉素、乙胺丁醇以及以下药物之一的方案：利福布汀、氯法齐明、阿米卡星或环丙沙星。对于TCD4 +淋巴细胞计数低于100/mm³的患者，建议使用利福布汀进行预防。