Winterleitner H, Palencia C, Knapp W, Eibl M, Krepler P
Padiatr Padol. 1975;10(3):237-43.
The rates of B and T-cell-subpopulations of lymphocytes were examined on 15 children with acute lymphatic leukemia during the first complete remission under maintenance in the Pinkel VII scheme and in 6 further cases with modification of this scheme of treatment compared to normal children in the same age groups. Further on 4 children during a relapse, on 1 during the second remission, and on 3 during long-term remissions. The most important result was a significant reduction of B cells during intensive maintenance therapy of the Pinkel scheme. In the few cases of long-term remissions a reduction of B cells was no longer observed.
在Pinkel VII方案维持治疗下,对15例处于首次完全缓解期的急性淋巴细胞白血病患儿以及另外6例与同年龄组正常儿童相比对该治疗方案进行了修改的患儿的淋巴细胞B和T细胞亚群比例进行了检测。此外,还检测了4例复发期患儿、1例第二次缓解期患儿以及3例长期缓解期患儿的情况。最重要的结果是在Pinkel方案的强化维持治疗期间B细胞显著减少。在少数长期缓解的病例中,未再观察到B细胞减少。