Bulkley B H, Roberts W C
Am J Cardiol. 1975 Nov;36(6):823-8. doi: 10.1016/0002-9149(75)90467-1.
Clinical and necropsy observations are described in a man in whom two sheep carotid arterial heterografts were inserted as aortocoronary bypass conduits 30 months before death, and in whom a canine saphenous vein heterograft was inserted several hours before death. All three grafts failed. The lumens of the sheep carotid arterial heterografts had closed by the time of catheterization 6 months after operation; at necropsy both grafts were totally occluded at their coronary and aortic ends and their media and adventitia were infiltrated by granulomatous inflammatory cells. Little information is available regarding the use of heterografts as coronary bypass conduits. Examination of previous reports describing heterografts for vascular reconstruction or bypass in both man and experimental animals and observations in our patient suggest that heterografts are unsatisfactory as aortocoronary bypass conduits.
本文描述了一名患者的临床及尸检观察结果。该患者在死亡前30个月植入了两根羊颈动脉异种移植物作为主动脉冠状动脉搭桥管道，并且在死亡前数小时植入了一根犬隐静脉异种移植物。所有三根移植物均失败。术后6个月进行导管插入术时，羊颈动脉异种移植物的管腔已闭合；尸检时，两根移植物在冠状动脉和主动脉端均完全闭塞，其中层和外膜被肉芽肿性炎症细胞浸润。关于异种移植物作为冠状动脉搭桥管道的应用，目前可用信息较少。查阅先前描述人类和实验动物中用于血管重建或搭桥的异种移植物的报告以及对我们这位患者的观察结果表明，异种移植物作为主动脉冠状动脉搭桥管道并不理想。
