Winfield J B, Winchester R J, Kunkel H G
Arthritis Rheum. 1975 Nov-Dec;18(6):587-94. doi: 10.1002/art.1780180609.
In a prospective study 26 of 29 patients with systemic lupus erythematosus had cold-reactive antilymphocyte antibodies cytotoxic for autologous lymphocytes and lymphocytes from normal subjects. The level of antilymphocyte antibodies was highly correlated, by linear regression analysis, with lymphopenia in these patients. The data suggested that both the avidity and the concentration of these antibodies were important determinants in this relationship. A clear association between increased antilymphocyte antibody activity and exacerbation of SLE was demonstrated. Apart from lymphopenia, however, neither type of clinical manifestation nor any particular serologic abnormality appeared to be related to the presence of antilymphocyte antibodies.
在一项前瞻性研究中，29例系统性红斑狼疮患者中有26例具有对自身淋巴细胞和正常受试者淋巴细胞具有细胞毒性的冷反应性抗淋巴细胞抗体。通过线性回归分析，这些患者的抗淋巴细胞抗体水平与淋巴细胞减少高度相关。数据表明，这些抗体的亲和力和浓度都是这种关系中的重要决定因素。抗淋巴细胞抗体活性增加与系统性红斑狼疮病情加重之间存在明显关联。然而，除淋巴细胞减少外，似乎没有任何一种临床表现类型或任何特定的血清学异常与抗淋巴细胞抗体的存在有关。
