Winfield J B, Winchester R J, Wernet P, Fu S M, Kunkel H G
Arthritis Rheum. 1975 Jan-Feb;18(1):1-8. doi: 10.1002/art.1780180101.
Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4 degrees C. IgG antibodies were infrequent, and were only minimally lymphocytotoxic. Most sera were cytotoxic for autologous lymphocytes and were equally reactive with normal and SLE lymphocytes, as well as with B- and T-cell preparations. Separate T- and B-cell specificities, which appeared not to be related to HL-A determinants, were identified by differential absorption experiments. The functional significance of these antilymphocyte antibodies is discussed.
通过微量细胞毒性和间接免疫荧光检测发现，系统性红斑狼疮（SLE）患者血清中的抗淋巴细胞抗体主要为冷反应性且属于IgM类。这些IgM抗体在4℃时活性最强。IgG抗体较少见，且淋巴细胞毒性极小。大多数血清对自体淋巴细胞具有细胞毒性，对正常淋巴细胞和SLE淋巴细胞以及B细胞和T细胞制剂的反应相同。通过差异吸收实验确定了单独的T细胞和B细胞特异性，这些特异性似乎与HL - A决定簇无关。本文讨论了这些抗淋巴细胞抗体的功能意义。
