Rosenthal M, Muller W
J Rheumatol. 1975 Dec;2(4):355-8.
Seventy-four normal persons, 48 patients with rheumatoid arthritis, and 25 patients with ankylosing spondylitis, were examined in respect to lymphocyte subpopulations in the peripheral blood. The simultaneous enumeration of T lymphocytes (E rosettes), B lymphocytes (surface immunoglobulin), as well as null cells and double marker cells was performed. No significant differences could be observed in the three examined groups in respect to the absolute or the relative lymphocyte counts, suggesting that possible immunological impairment assumed in rheumatoid arthritis and ankylosing spondylitis, is due not to reduced cell numbers, but to a possible functional disorder.
对74名正常人、48名类风湿性关节炎患者和25名强直性脊柱炎患者的外周血淋巴细胞亚群进行了检测。同时对T淋巴细胞（E玫瑰花结）、B淋巴细胞（表面免疫球蛋白）以及裸细胞和双标记细胞进行了计数。在三组检测对象中，绝对淋巴细胞计数或相对淋巴细胞计数均未观察到显著差异，这表明类风湿性关节炎和强直性脊柱炎中假定的可能免疫损伤并非由于细胞数量减少，而是可能由于功能紊乱。
