Meijer C J, Lafeber G J, Cnossen J, Damsteeg M G, Cats A
J Rheumatol. 1982 Jan-Feb;9(1):18-24.
The number of various lymphocyte subpopulations in the peripheral blood of 28 patients with definite rheumatoid arthritis (RA) were studied. The results were correlated with the disease activity, as assessed by the Ritchie index, erythrocyte sedimentation rate and clinical impression. Patients with active RA showed decreased numbers of T mu lymphocytes, strongly increased numbers of Tnull lymphocytes and slightly increased percentages of Fc gamma lymphocytes as compared to 22 healthy donors. Patients with inactive RA had similar, less striking, but significant changes in T mu and Tnull lymphocytes, but in contrast to patients with active RA had Increased numbers of T gamma lymphocytes. The imbalances in T mu and Tnull cells in patients with RA might be explained by endogenous T mu cell activation, resulting in increased numbers of Tnull cells.
对28例确诊为类风湿性关节炎（RA）患者外周血中各种淋巴细胞亚群的数量进行了研究。结果与通过里奇指数、红细胞沉降率和临床印象评估的疾病活动度相关。与22名健康供体相比，活动性RA患者的Tμ淋巴细胞数量减少，T无淋巴细胞数量大幅增加，Fcγ淋巴细胞百分比略有增加。非活动性RA患者的Tμ和T无淋巴细胞有类似的、不太显著但有统计学意义的变化，但与活动性RA患者不同的是，其Tγ淋巴细胞数量增加。RA患者Tμ和T无细胞的失衡可能是由内源性Tμ细胞活化导致T无细胞数量增加所致。
