Sinha D P, Bang F B
Am J Clin Nutr. 1976 Jan;29(1):110-5. doi: 10.1093/ajcn/29.1.110.
Marked seasonal variation in the prevalence of signs of vitamin A deficiency was found in the 2nd year of a continuing study of children age 0 to 4-1/2 years in a village in West Bengal, confirming results of a previous 18-month study. Administration of 200,000 IU of vitamin A every 4 months completely eliminated night blindness and prevented the development of new cases of Bitot's spot in a statistically significant number of children. The effectiveness of massive doses of vitamin A, administered at intervals of 4 months, as a short-term measure to fight the problem, was confirmed in this village. The study yielded additional evidence of the complex etiology of Bitot's spot, since alternate day dose of vitamin A in addition to massive therapy failed to eliminate these spots.
在西孟加拉邦一个村庄对0至4岁半儿童进行的一项持续研究的第二年，发现维生素A缺乏体征的患病率存在明显的季节性变化，这证实了之前一项为期18个月研究的结果。每4个月给予20万国际单位的维生素A，在统计学上显著数量的儿童中完全消除了夜盲症，并预防了新的毕脱斑病例的出现。在这个村庄证实了每4个月间隔给予大剂量维生素A作为对抗该问题的短期措施的有效性。该研究还提供了更多关于毕脱斑复杂病因的证据，因为除了大剂量治疗外，隔天给予维生素A未能消除这些斑点。
