气管内注射重组人脱氧核糖核酸酶治疗常规治疗无效的急性危及生命的哮喘
Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment.
作者信息
Patel A, Harrison E, Durward A, Murdoch I A
机构信息
Department of Paediatric Intensive Care, Guy's Hospital, London, UK.
出版信息
Br J Anaesth. 2000 Apr;84(4):505-7. doi: 10.1093/oxfordjournals.bja.a013479.
Abstract
Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.
摘要
重组人脱氧核糖核酸酶（rhDNase）是一种黏液溶解剂，用于缓解囊性纤维化患者的外周气道阻塞。我们报告了一名3岁患有急性危及生命哮喘的男孩，在积极治疗48小时失败后，经气管内给予rhDNase后病情显著持续改善。
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