Pediatric Intensive Care Unit, Amsterdam UMC, Emma Children's Hospital, Location AMC, Amsterdam, the Netherlands.
Pediatric Pulmonary Medicine, Children's Hospital of Richmond, Virginia Commonwealth University, United States.
Paediatr Respir Rev. 2020 Nov;36:8-14. doi: 10.1016/j.prrv.2020.06.007. Epub 2020 Jun 16.
Many airway diseases in children, notably bronchiolitis, cystic fibrosis (CF), non-CF bronchiectasis including primary ciliary dyskinesia, pneumonia, and severe asthma are associated with retention of airway secretions. Medications to improve secretions clearance, the mucoactive medications, are employed to treat these diseases with varying degrees of success. This manuscript reviews evidence for the use of these medications and future directions of study.
许多儿童气道疾病，特别是细支气管炎、囊性纤维化（CF）、非 CF 支气管扩张症（包括原发性纤毛运动障碍）、肺炎和严重哮喘，与气道分泌物潴留有关。为了治疗这些疾病，人们使用了能改善分泌物清除的药物，即黏液促排药物，这些药物在一定程度上取得了成功。本文综述了这些药物的使用证据和未来的研究方向。
