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子宫壁中的纤溶酶原激活剂及其他类胰蛋白酶及其在组织出血中的作用(作者译)

[Plasminogen activator and other trypsin-like proteases in the uterus wall and their participation on the tissue bleeding (author's transl)].

作者信息

Koutský J, Rybák M, Rybáková B

出版信息

Arch Gynakol. 1975 Dec 16;220(1):11-8. doi: 10.1007/BF00673144.

Abstract

In the myometrium and endometrium a content of plasminogen activator and non-specific trypsin-like proteases was determined. It was ascertained that there was a higher level of plasminogen activator in the endometrium during the menstruation in the contrary to the first and second phase of the menstrual cycle and that both plasminogen activator and non-specific trypsin-like proteases were relative higher in Corpusmyometrium than those Cervixmyometrium. The proteases present in the fractions of myometriumeluate were able to split casein and partially fibrin, too. These activities were not inhibited by epsilon aminocaproic acid and aprotinin. The importance of these findings for gynaecological bleeding was suggested.

摘要

测定了子宫肌层和子宫内膜中纤溶酶原激活物和非特异性类胰蛋白酶的含量。结果确定,与月经周期的第一和第二阶段相反,子宫内膜在月经期间纤溶酶原激活物水平较高,并且子宫体肌层中的纤溶酶原激活物和非特异性类胰蛋白酶均比子宫颈肌层中的相对更高。子宫肌层洗脱液各组分中的蛋白酶也能够分解酪蛋白和部分纤维蛋白。这些活性不受ε-氨基己酸和抑肽酶的抑制。提示了这些发现对妇科出血的重要性。

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