Shaw S T, Macaulay L K, Sun N C, Tanaka M S, Roche P C
Contraception. 1983 Feb;27(2):131-40. doi: 10.1016/0010-7824(83)90084-7.
Potassium thiocyanate-extractable uterine plasminogen activator activity was determined to be highest in the endometrium surrounding intrauterine devices (IUDs). Such activity was significantly higher than that encountered in control endometrium or in the endometrium remote to IUDs. As in control cases, extracted endometrial activity fluctuated during the intermenstrual ovarian cycle. It was highest in the pre- or periovulation part of the cycle, and it rose again prior to menstruation. These peaks of activity seem to correspond to times in the cycle when metrorrhagia and abnormal menstruation are usually encountered. Possible implications of the myometrial and endometrial patterns of plasminogen activator in control and IUD-exposed uterine tissue are discussed.
经测定，硫氰酸钾可提取的子宫纤溶酶原激活物活性在宫内节育器（IUD）周围的子宫内膜中最高。这种活性显著高于对照子宫内膜或远离IUD的子宫内膜中的活性。与对照病例一样，提取的子宫内膜活性在月经周期的卵巢周期中会发生波动。在周期的排卵前或排卵期最高，在月经前再次升高。这些活性峰值似乎与通常出现子宫出血和月经异常的周期时间相对应。本文讨论了纤溶酶原激活物在对照子宫组织和暴露于IUD的子宫组织中的肌层和内膜模式的可能影响。
