Sharma N C, Galustians H J, Qaquish J, Galustians A, Rustogi K N, Petrone M E, Chaknis P, Garcia L, Volpe A R, Proskin H M
BioSci Research Canada Ltd., Mississauga, Ontario, Canada.
J Clin Dent. 1999;10(4):131-4.
The objective of this double-blind clinical study was to investigate the effectiveness of a dentifrice containing triclosan and a copolymer, Colgate Total Toothpaste, for controlling breath odor twelve hours after brushing the teeth compared to a placebo dentifrice which did not contain triclosan or a copolymer. Breath odor was evaluated by a panel of four expert judges using a nine-point hedonic scale. Following a baseline evaluation of breath odor, prospective study subjects who presented scores above the threshold value for unpleasant breath odor were stratified by score, and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush, and brushed their teeth thoroughly in their regular and customary manner with their assigned dentifrice. Subjects refrained from dental hygiene, breath mints, or mouth rinses for the next twelve hours, after which they were once again evaluated for breath odor. Sixty-three (63) adult male and female subjects from the Mississauga, Ontario, Canada area participated in the study. At twelve hours after brushing their teeth, subjects in both dentifrice treatment groups presented mean breath odor scores which were statistically significantly lower than the mean scores observed at baseline. However, the difference between the mean twelve-hour breath odor scores differed significantly between the two dentifrices. The mean twelve-hour breath odor score for the Colgate Total Toothpaste group was 4.77, which is within the range of values corresponding to pleasant breath odor; the mean twelve-hour breath odor score for the placebo group was 6.05, which is above the value corresponding to unpleasant breath odor. Thus, the results of this double-blind clinical study support the conclusion that Colgate Total Toothpaste provides effective control of breath odor at twelve hours after brushing the teeth.
这项双盲临床研究的目的是，与不含三氯生或共聚物的安慰剂牙膏相比，调查含有三氯生和共聚物的牙膏（高露洁全效牙膏）在刷牙12小时后控制口气异味的效果。由四名专家评委组成的小组使用九点享乐量表对口气异味进行评估。在对口气异味进行基线评估之后，将口气异味评分高于阈值的前瞻性研究对象按评分分层，并随机分为两个治疗组。为研究对象提供软毛牙刷，让他们用指定的牙膏以常规习惯方式彻底刷牙。在接下来的12小时内，研究对象不进行牙齿清洁、不使用口气清新糖或漱口水，之后再次对他们的口气异味进行评估。来自加拿大安大略省密西沙加地区的63名成年男性和女性参与了该研究。刷牙12小时后，两个牙膏治疗组的研究对象的平均口气异味评分在统计学上均显著低于基线时观察到的平均评分。然而，两种牙膏的12小时平均口气异味评分之间存在显著差异。高露洁全效牙膏组的12小时平均口气异味评分为4.77，处于对应口气清新的数值范围内；安慰剂组的12小时平均口气异味评分为6.05，高于对应口气不佳的数值。因此，这项双盲临床研究的结果支持以下结论：高露洁全效牙膏在刷牙12小时后能有效控制口气异味。
