Vizirenko L V, Kondrattsova T P, Vershigora A E
Zh Mikrobiol Epidemiol Immunobiol. 1975 Dec(12):82-5.
A study was made of the production of a blastogenic factor and lymphotoxin in the cultures of lymphocytes of the palatine tonsils removed from patients with chronic tonsillitis; the activity of this blastogenic factor and lymphotoxin was studied in the test-cultures of autologous and allogenic lymphocytes and the transplantable HeLa cells. The antigens of the pathogenic streptococcus and staphylococcus induced production of the blastogenic factor and lymphotoxin; as to the antigens of saprophytic bacteria-they produced no such action. The antigen-specific blastogenic factor intensified the immune response to the homologous antigen, whereas the factor obtained in stimulation of lymphocytes with PHA-to all the microbial antigens under study.
对从慢性扁桃体炎患者切除的腭扁桃体淋巴细胞培养物中促有丝分裂因子和淋巴毒素的产生进行了研究；在自体和同种异体淋巴细胞以及可移植的HeLa细胞的测试培养物中研究了这种促有丝分裂因子和淋巴毒素的活性。致病性链球菌和葡萄球菌的抗原诱导促有丝分裂因子和淋巴毒素的产生；至于腐生菌的抗原——它们没有产生这种作用。抗原特异性促有丝分裂因子增强了对同源抗原的免疫反应，而用PHA刺激淋巴细胞获得的因子——对所有研究的微生物抗原都有增强作用。
