Beuzeron-Mangina J H, Mangina C A
McGill University and World Health Organization Research Program, Montreal Research and Treatment Center, Neurophysiology Section and Memory Clinic, Douglas Hospital, Montreal, Quebec, Canada.
Int J Psychophysiol. 2000 Jul;37(1):55-69. doi: 10.1016/s0167-8760(00)00095-7.
Our previous research with intra-cerebral event-related potentials in conjunction with an original Memory Workload Paradigm has shown that significant load effects for the N4 latency were found only for both amygdalae and the left posterior hippocampus as well as for both anterior neo-cortical regions of the temporal gyri. These same structures are also affected in Alzheimer's Disease. Therefore, based on our previous intra-cerebral findings, our present research was to use our novel Memory Workload Paradigm in conjunction with surface ERPs as neurophysiological markers to tap cerebral regions and functions involved in memory disorders pertaining to early Alzheimer's Disease as opposed to normal memory processes in age-matched normal control subjects. Moreover, the Mangina-Test which measures varying degrees of 'Analytical-Specific Visual Perception' was individually administered to all patients and controls in separate sessions. Results indicate that for the early Alzheimer's Disease group, a significant main effect for memory load was found for the P400 amplitude (F(3,30)=4.52, P<0.02) which was absent in the normal group. In particular, the P400 amplitude was significantly higher on posterior head regions for patients with early Alzheimer's Disease as opposed to age-matched normal subjects (F(7,140)=3.54, P<0.03) which distinguished both groups (F(1,20)=6. 13, P<0.03). For the P400 latency, a significant memory load effect was present only for the normal group (F(3,30)=11.26, P<0.01). The Mangina-Test performance clearly differentiated both groups (F(1, 19)=105.85, P<0.001). The present data provide the first valuable evidence that ERPs to our novel Memory Workload Paradigm are sensitive neurophysiological diagnostic markers which delineate the early clinical brain irregularities underlying early Alzheimer's Disease as opposed to the normal memory processes of age-matched normal subjects. In addition, their use could be valuable for the objective clinical follow-up of therapeutic interventions in early Alzheimer's Disease.
我们之前结合原创的记忆负荷范式进行的脑内事件相关电位研究表明，仅在双侧杏仁核、左侧海马后部以及颞叶的双侧前新皮质区域发现了N4潜伏期的显著负荷效应。这些相同的结构在阿尔茨海默病中也会受到影响。因此，基于我们之前的脑内研究结果，我们目前的研究是将我们新颖的记忆负荷范式与表面事件相关电位结合起来，作为神经生理标志物，以探究与早期阿尔茨海默病相关的记忆障碍所涉及的脑区和功能，对比年龄匹配的正常对照受试者的正常记忆过程。此外，对所有患者和对照分别进行了测量不同程度“分析性特定视觉感知”的曼吉纳测试。结果表明，对于早期阿尔茨海默病组，P400波幅存在显著的记忆负荷主效应（F(3,30)=4.52，P<0.02），而正常组不存在此效应。特别是，与年龄匹配的正常受试者相比，早期阿尔茨海默病患者后头部区域的P400波幅显著更高（F(7,140)=3.54，P<0.03），这区分了两组（F(1,20)=6.13，P<0.03）。对于P400潜伏期，仅正常组存在显著的记忆负荷效应（F(3,30)=11.26，P<0.01）。曼吉纳测试的表现明显区分了两组（F(1,19)=105.85，P<0.001）。目前的数据提供了首个有价值的证据，即针对我们新颖的记忆负荷范式的事件相关电位是敏感的神经生理诊断标志物，它描绘了早期阿尔茨海默病潜在的早期临床脑异常，对比年龄匹配的正常受试者的正常记忆过程。此外，它们的应用对于早期阿尔茨海默病治疗干预的客观临床随访可能具有重要价值。
