Tendolkar I, Schoenfeld A, Golz G, Fernández G, Kühl K P, Ferszt R, Heinze H J
Department of Neurology II, University of Magdeburg, Germany.
Neurosci Lett. 1999 Mar 19;263(1):45-8. doi: 10.1016/s0304-3940(99)00106-8.
To dissociate recognition memory with and without recollection, event-related potentials (ERPs) of patients with Alzheimer's disease (AD) and matched controls were recorded in a test of verbal recognition memory accompanied by a source judgement. AD patients who had smaller hippocampi showed a disability to recollect the study context (source). Their ERPs elicited by correctly recognized old words compared to new items were more positive only between 300 and 500 ms with a maximum over the frontal scalp. Controls exhibited a sustained old/new effect over left temporoparietal and frontal sites. The present findings suggest that preserved recognition memory in patients with mild AD is independent of hippocampally mediated processes recollecting episodic memories.
为了区分有回忆和无回忆情况下的识别记忆，在一项伴有来源判断的言语识别记忆测试中，记录了阿尔茨海默病（AD）患者及匹配对照组的事件相关电位（ERP）。海马较小的AD患者表现出回忆学习情境（来源）的障碍。与新项目相比，由正确识别的旧词诱发的他们的ERP仅在300至500毫秒之间更正向，在额部头皮处达到最大值。对照组在左侧颞顶叶和额部区域表现出持续的新旧效应。目前的研究结果表明，轻度AD患者中保留的识别记忆独立于海马介导的情景记忆回忆过程。
