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2

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J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.

3

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J Exp Med. 1976 Apr 1;143(4):889-96. doi: 10.1084/jem.143.4.889.

4

Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.

J Exp Med. 1976 Apr 1;143(4):906-18. doi: 10.1084/jem.143.4.906.

5

Mechanisms of action of genes controlling the immune response.

Transplant Proc. 1975 Jun;7(2):141-7.

6

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7

T lymphocyte-enriched murine peritoneal exudate cells. I. A reliable assay for antigen-induced T lymphocyte proliferation.

J Immunol. 1975 Nov;115(5):1330-8.

8

Two genes in the major histocompatibility complex control immune response.

Nature. 1975 Jul 10;256(5513):103-6. doi: 10.1038/256103a0.

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在对聚（谷氨酸53-赖氨酸36-苯丙氨酸11）的T淋巴细胞增殖反应中，对两个互补的Ir-GLphi免疫反应基因的需求。

The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).

作者信息

Schwartz R H, Dorf M E, Benacerraf B, Paul W E

出版信息

J Exp Med. 1976 Apr 1;143(4):897-905. doi: 10.1084/jem.143.4.897.

DOI:10.1084/jem.143.4.897

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190158/

Abstract

The antibody response to poly-(Glu53Lys36Phe11) (GLphi) has been shown to be under the control of two independent, major histocompatibility-linked immune response genes, designated alpha and beta. In the present work we demonstrate that the T-lymphocyte proliferative response is also under the control of these two immune response genes. Thus, mice of the H-2a, H-2b, H-2k, and H-2s haplotypes were all nonresponders to GLphi. In contrast F1 hybrids between these strains, such as (B10 X B10.A)F1 and (C3H X SJL)F1, as well as several recombinant mice derived from the nonresponder haplotypes, such as B10.1(5R), B10.HTT, and B10.S(9R), were all responders to GLphi. The complementation between nonresponder genomes appeared to be stronger in the cis position than in the trans position for some strain combinations. The failure of strains bearing only one of the two responder alleles to show a T-lymphocyte proliferative response to GLphi, argues strongly that neither gene can be expressed exclusively in B lymphocytes. This conclusion is discussed in relation to another two gene model which has recently been proposed.

摘要

对聚（Glu53Lys36Phe11）（GLphi）的抗体反应已被证明受两个独立的、与主要组织相容性相关的免疫反应基因控制，分别命名为α和β。在本研究中，我们证明T淋巴细胞增殖反应也受这两个免疫反应基因的控制。因此，H-2a、H-2b、H-2k和H-2s单倍型的小鼠对GLphi均无反应。相比之下，这些品系之间的F1杂种，如（B10×B10.A）F1和（C3H×SJL）F1，以及一些源自无反应单倍型的重组小鼠，如B10.1（5R）、B10.HTT和B10.S（9R），对GLphi均有反应。对于某些品系组合，无反应基因组之间的互补在顺式位置似乎比反式位置更强。仅携带两个反应等位基因之一的品系未能对GLphi表现出T淋巴细胞增殖反应，这有力地表明这两个基因都不能仅在B淋巴细胞中表达。结合最近提出的另一个双基因模型对这一结论进行了讨论。