Dorf M E, Maurer P H, Merryman F, Benacerraf B
J Exp Med. 1976 Apr 1;143(4):889-96. doi: 10.1084/jem.143.4.889.
The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly-(glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed.
对L-氨基酸的无规线性三元共聚物、聚(谷氨酰胺57、赖氨酸38、酪氨酸5)、聚(谷氨酰胺51、赖氨酸34、酪氨酸15)和聚(谷氨酰胺53、赖氨酸36、苯丙氨酸11)的免疫反应均由两个显性H连锁Ir基因控制。然而,对这三种相关三元共聚物的免疫反应表现出不同的H-2分布,这些H-2模式是单个包含组系统的一部分。α基因和β基因是显性的;然而,当两个基因处于顺式构型时,最有效的基因相互作用才会发生。本文讨论了这种顺反效应的潜在意义。