由两个互补的Ir-GLphi基因控制的反应中的包含组系统和顺反效应。
Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes.
作者信息
Dorf M E, Maurer P H, Merryman F, Benacerraf B
出版信息
J Exp Med. 1976 Apr 1;143(4):889-96. doi: 10.1084/jem.143.4.889.
Abstract
The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly-(glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed.
摘要
对L-氨基酸的无规线性三元共聚物、聚（谷氨酰胺57、赖氨酸38、酪氨酸5）、聚（谷氨酰胺51、赖氨酸34、酪氨酸15）和聚（谷氨酰胺53、赖氨酸36、苯丙氨酸11）的免疫反应均由两个显性H连锁Ir基因控制。然而，对这三种相关三元共聚物的免疫反应表现出不同的H-2分布，这些H-2模式是单个包含组系统的一部分。α基因和β基因是显性的；然而，当两个基因处于顺式构型时，最有效的基因相互作用才会发生。本文讨论了这种顺反效应的潜在意义。
相似文献
1
Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes.由两个互补的Ir-GLphi基因控制的反应中的包含组系统和顺反效应。
J Exp Med. 1976 Apr 1;143(4):889-96. doi: 10.1084/jem.143.4.889.
2
The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).在对聚（谷氨酸53-赖氨酸36-苯丙氨酸11）的T淋巴细胞增殖反应中，对两个互补的Ir-GLphi免疫反应基因的需求。
J Exp Med. 1976 Apr 1;143(4):897-905. doi: 10.1084/jem.143.4.897.
3
Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.两个互补的Ir-GLphi免疫反应基因对T淋巴细胞和B淋巴细胞激活的控制
J Exp Med. 1976 Apr 1;143(4):906-18. doi: 10.1084/jem.143.4.906.
4
Gene complementation in the T-lymphocyte proliferative response to poly (Glu55Lys36Phe9)n. A demonstration that both immune response gene products must be expressed in the same antigen-presenting cell.T淋巴细胞对聚（谷氨酸55-赖氨酸36-苯丙氨酸9）n增殖反应中的基因互补作用。证明两种免疫反应基因产物必须在同一个抗原呈递细胞中表达。
J Exp Med. 1979 Jan 1;149(1):40-57. doi: 10.1084/jem.149.1.40.
5
Expression of a single major histocompatibility complex locus controls the immune response to poly-L-(tyrosine, glutamic acid)-poly-DL-alanine-poly-L-lysine.单个主要组织相容性复合体基因座的表达控制对聚-L-（酪氨酸，谷氨酸）-聚-DL-丙氨酸-聚-L-赖氨酸的免疫反应。
J Exp Med. 1978 Feb 1;147(2):599-604. doi: 10.1084/jem.147.2.599.
6
Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.体外抗体应答的细胞与遗传控制。II. 对聚-L-（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸及聚-L-（组氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸的三硝基苯基缀合物的初次IgM应答的Ir基因控制
J Exp Med. 1977 Oct 1;146(4):1096-107. doi: 10.1084/jem.146.4.1096.
7
Complementation of H-2-linked Ir genes in the mouse.小鼠中H-2连锁Ir基因的互补作用。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3671-5. doi: 10.1073/pnas.72.9.3671.
8
Presence of common idiotypes on antibodies induced by glutamic acid-lysine-containing terpolymers in responder and nonresponder mice with the Ig-1b heavy chain allotype.在具有Ig-1b重链同种异型的应答和不应答小鼠中，由含谷氨酸-赖氨酸的三元共聚物诱导产生的抗体上存在共同独特型。
Eur J Immunol. 1977 Dec;7(12):865-71. doi: 10.1002/eji.1830071209.
9
Genetic control of the immune response to the radom linear terpolymer of L-glutamic acid, L-lysine and L-leucine (GLleu) by complementing Ir genes.通过互补免疫反应基因对L-谷氨酸、L-赖氨酸和L-亮氨酸（GLleu）的无规线性三元共聚物的免疫反应进行遗传控制。
Eur J Immunol. 1976 Aug;6(8):552-6. doi: 10.1002/eji.1830060805.
引用本文的文献
1
Role of the H-2s haplotype in survival of mice after infection with Trypanosoma cruzi.H-2s单倍型在克氏锥虫感染后小鼠存活中的作用。
Infect Immun. 1984 May;44(2):351-4. doi: 10.1128/iai.44.2.351-354.1984.
2
Expression of the I-E target antigen for T-cell killing requires two genes.用于T细胞杀伤的I-E靶抗原的表达需要两个基因。
Immunogenetics. 1980;11(6):571-83. doi: 10.1007/BF01567826.
3
Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. II. Competitive inhibition of I-E-restricted, antigen-specific T cell responses.结构相关的Ir基因控制的聚合物对抗原特异性T淋巴细胞激活的抑制作用。II. I-E限制的抗原特异性T细胞应答的竞争性抑制
J Exp Med. 1984 Dec 1;160(6):1864-79. doi: 10.1084/jem.160.6.1864.
4
HLA-linked and unlinked determinants of multiple sclerosis.多发性硬化症的HLA连锁和非连锁决定因素。
Immunogenetics. 1982;15(5):509-17. doi: 10.1007/BF00345910.
5
The expression of anti-poly(LGlu60, LPhe40) idiotypic determinants dictated by the gene products in the major histocompatibility complex.由主要组织相容性复合体中的基因产物所决定的抗聚（L-谷氨酸60，L-苯丙氨酸40）独特型决定簇的表达。
J Exp Med. 1981 Sep 1;154(3):649-58. doi: 10.1084/jem.154.3.649.
6
Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.两个互补的Ir-GLphi免疫反应基因对T淋巴细胞和B淋巴细胞激活的控制
J Exp Med. 1976 Apr 1;143(4):906-18. doi: 10.1084/jem.143.4.906.
7
The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).在对聚（谷氨酸53-赖氨酸36-苯丙氨酸11）的T淋巴细胞增殖反应中，对两个互补的Ir-GLphi免疫反应基因的需求。
J Exp Med. 1976 Apr 1;143(4):897-905. doi: 10.1084/jem.143.4.897.
8
The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.控制主要组织相容性复合体、备解素因子B和补体第二成分缺陷的基因的染色体顺序。
J Clin Invest. 1976 Nov;58(5):1240-8. doi: 10.1172/JCI108578.
9
The immune response of allophenic mice to the synthetic polymer L-glutamic acid, L-lysine, L-phenylalanine. II. Lack of gene complementation in two nonresponder strains.异表型小鼠对合成聚合物L-谷氨酸、L-赖氨酸、L-苯丙氨酸的免疫反应。II. 两个无反应品系中缺乏基因互补。
J Exp Med. 1977 Mar 1;145(3):766-71. doi: 10.1084/jem.145.3.766.
10
Coupled complementation of immune response genes controlling responsiveness to the H-2.2 alloantigen.控制对H-2.2同种抗原反应性的免疫反应基因的偶联互补作用。
J Exp Med. 1977 Aug 1;146(2):571-8. doi: 10.1084/jem.146.2.571.
本文引用的文献
1
Distribution of allotypic specificities A1, A2, A14, and A15 among immunoglobulin G molecules.免疫球蛋白G分子中同种异型特异性A1、A2、A14和A15的分布。
J Immunol. 1970 Mar;104(3):641-7.
2
Idiotype expression and the inheritance of mouse antibody clones.独特型表达与小鼠抗体克隆的遗传
J Exp Med. 1973 Mar 1;137(3):603-21. doi: 10.1084/jem.137.3.603.
3
Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
4
Mapping of the immune response genes in the major histocompatibility complex of the Rhesus monkey.恒河猴主要组织相容性复合体中免疫反应基因的图谱绘制。
J Exp Med. 1975 Sep 1;142(3):673-93. doi: 10.1084/jem.142.3.673.
5
Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.两个互补的Ir-GLphi免疫反应基因对T淋巴细胞和B淋巴细胞激活的控制
J Exp Med. 1976 Apr 1;143(4):906-18. doi: 10.1084/jem.143.4.906.
6
The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).在对聚（谷氨酸53-赖氨酸36-苯丙氨酸11）的T淋巴细胞增殖反应中，对两个互补的Ir-GLphi免疫反应基因的需求。
J Exp Med. 1976 Apr 1;143(4):897-905. doi: 10.1084/jem.143.4.897.
7
Complementation of H-2-linked Ir genes in the mouse.小鼠中H-2连锁Ir基因的互补作用。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3671-5. doi: 10.1073/pnas.72.9.3671.
8
The histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因。
Adv Cancer Res. 1975;21:121-73. doi: 10.1016/s0065-230x(08)60972-0.
9
Two genes in the major histocompatibility complex control immune response.主要组织相容性复合体中的两个基因控制免疫反应。
Nature. 1975 Jul 10;256(5513):103-6. doi: 10.1038/256103a0.
Zotero 插件