抗原反应性T克隆。III.低反应性抗原呈递细胞能有效地将抗原呈递给源自（高反应性×低反应性）F1小鼠的选定T细胞克隆。
Antigen-reactive T clones. III. Low responder antigen-presenting cells function effectively to present antigen to selected T cell clones derived from (High Responder x Low Responder)F1 mice.
作者信息
Kimoto M, Krenz T J, Fathman C G
出版信息
J Exp Med. 1981 Sep 1;154(3):883-91. doi: 10.1084/jem.154.3.883.
Abstract
Long-term-cultured poly(Tyr, Glu)-poly-D,L,-Ala-poly-Lys [(T,G)-A--L]-reactive T cells and clones derived from (high responder x low responder)F1 [(C57BL/6 x A/J)F1] mice were shown to recognize (T,G)-A--L presented by cells from low responder strain A/J mice. The antigen-presenting determinant(s) that allowed recognition of (T,G)-A--L by such T cell clones was controlled by the I-A subregion of the major histocompatibility complex. These results suggest that there is no functional defect in the ability of low responder Ir gene products (I-A antigens) to associate with (T,G)-A--L for effective recognition by T cells. Although these results might tentatively be interpreted to suggest that Ir gene-controlled low responsiveness is due to the inability of the T cell to recognize the association between (T,G)-A--L and low responder I-A gene products, it is similarly possible that there might be a defect in the functional capabilities of low responder antigen-presenting cells to effectively process (T,G)-A--L into immunodominant epitopes.
摘要
长期培养的聚（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚赖氨酸[（T，G）-A-L]反应性T细胞以及源自（高反应性×低反应性）F1[（C57BL/6×A/J）F1]小鼠的克隆被证明能够识别低反应性品系A/J小鼠细胞所呈递的（T，G）-A-L。此类T细胞克隆识别（T，G）-A-L的抗原呈递决定簇由主要组织相容性复合体的I-A亚区控制。这些结果表明，低反应性Ir基因产物（I-A抗原）与（T，G）-A-L结合以供T细胞有效识别的能力不存在功能缺陷。尽管这些结果可能初步被解释为表明Ir基因控制的低反应性是由于T细胞无法识别（T，G）-A-L与低反应性I-A基因产物之间的结合，但同样有可能低反应性抗原呈递细胞将（T，G）-A-L有效加工成免疫显性表位的功能能力存在缺陷。
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