Nakanishi N, Nakamura K, Suzuki K, Tatara K
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Japan.
Occup Med (Lond). 2000 Feb;50(2):115-20. doi: 10.1093/occmed/50.2.115.
The association of lifestyle factors with serum gamma-glutamyltransferase (GGT) was examined in 1176 Japanese male office workers aged 40-59 years. Those who had serum aminotransferase levels exceeding the normal range and/or who took prescription medication for, or had a past history of, liver disease were excluded. From the logistic regression analysis, lifestyle factors showing a positive association with high serum GGT (> or = 60 U/l) were body mass index, alcohol intake, cigarette smoking, and snacking between meals. On the other hand, coffee drinking showed an inverse association with high serum GGT. As for the relationships between snacking between meals and other lifestyle factors, snacking between meals was significantly related to alcohol intake (negative) and coffee drinking. Influences of snacking between meals on serum GGT are likely to be indirectly mediated through coping mechanisms of less alcohol drinking and more coffee drinking. Our findings support the conclusions that alcohol drinking, obesity, and cigarette smoking are positively associated with raised serum GGT and that coffee consumption is inversely related to raised serum GGT.
在1176名年龄在40 - 59岁的日本男性上班族中，研究了生活方式因素与血清γ-谷氨酰转移酶（GGT）之间的关联。排除了血清转氨酶水平超过正常范围和/或正在服用治疗肝病的处方药或有肝病病史的人。从逻辑回归分析来看，与高血清GGT（≥60 U/l）呈正相关的生活方式因素有体重指数、饮酒量、吸烟以及餐间吃零食。另一方面，喝咖啡与高血清GGT呈负相关。至于餐间吃零食与其他生活方式因素之间的关系，餐间吃零食与饮酒量（负相关）和喝咖啡显著相关。餐间吃零食对血清GGT的影响可能是通过减少饮酒量和增加喝咖啡量的应对机制间接介导的。我们的研究结果支持以下结论：饮酒、肥胖和吸烟与血清GGT升高呈正相关，而咖啡消费与血清GGT升高呈负相关。
