García-Hermoso Antonio, Hackney Anthony C, Ramírez-Vélez Robinson
Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Santiago, Chile.
Endocrine Section-Applied Physiology Laboratory, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
PLoS One. 2017 Oct 19;12(10):e0185908. doi: 10.1371/journal.pone.0185908. eCollection 2017.
High levels of gamma glutamyltransferase (gamma-GT) and alanine aminotransferase (ALT), as well as fatty liver index (FLI) has been associated with higher cardiovascular disease risk factors in adults. The aim of this study was to examine the relationship between gamma-GT, ALT, and fatty liver index FLI levels across a gradient number of ideal cardiovascular health metrics in a representative sample of adults from the Chilean National Health Survey 2009-2010. Data from 1,023 men and 1,449 women (≥ 15 years) from the Chilean Health Survey 2009-2010 were analyzed. Ideal cardiovascular health was defined as meeting ideal levels of the following components: four behaviours (smoking, body mass index, physical activity and diet adherence) and three factors (total cholesterol, blood pressure and fasting glucose). Adults were grouped into three categories according to their number of ideal cardiovascular health metrics: ideal (5-7 metrics), intermediate (3-4 metrics), and poor (0-2 metrics). Blood levels of gamma-GT and ALT were measured and the FLI was calculated. A higher number of ideal cardiovascular health index metric was associated with lower gamma-GT, ALT and FLI (p from trend analysis <0.001). Also, adults meeting at least 3-4 metrics were predicted less likely to have prevalence of abnormal levels of gamma-GT and FLI (p<0.001) compared to adults who met only 0-2 metrics. These findings reinforce the usefulness of the ideal cardiovascular health metrics proposed by the American Heart Association as a tool to identify target subjects and promote cardiovascular health in South-American adults.
高水平的γ-谷氨酰转移酶（γ-GT）、丙氨酸氨基转移酶（ALT）以及脂肪肝指数（FLI）与成年人较高的心血管疾病风险因素相关。本研究的目的是在2009 - 2010年智利全国健康调查的具有代表性的成年人样本中，考察γ-GT、ALT和脂肪肝指数FLI水平与一系列理想心血管健康指标之间的关系。对来自2009 - 2010年智利健康调查的1023名男性和1449名女性（≥15岁）的数据进行了分析。理想心血管健康被定义为达到以下各项的理想水平：四种行为（吸烟、体重指数、身体活动和饮食依从性）和三个因素（总胆固醇、血压和空腹血糖）。成年人根据其理想心血管健康指标的数量分为三类：理想（5 - 7项指标）、中等（3 - 4项指标）和较差（0 - 2项指标）。测量了γ-GT和ALT的血液水平并计算了FLI。理想心血管健康指标数量越多，γ-GT、ALT和FLI越低（趋势分析p<0.001）。此外，与仅符合0 - 2项指标的成年人相比，符合至少3 - 4项指标的成年人被预测γ-GT和FLI异常水平的患病率较低（p<0.001）。这些发现强化了美国心脏协会提出的理想心血管健康指标作为识别目标人群和促进南美成年人心血管健康工具的有用性。
