照射小鼠胸腺和脾脏中标记DNA的释放与保留
Release and retention of labelled DNA in the thymus and spleen of irradiated mice.
作者信息
Suciu D, Uray Z, Abraham A D
出版信息
Strahlentherapie. 1976 Feb;151(2):156-61.
The process of release and retention of labelled DNA in thymus and spleen of normal and irradiated (60Co) mice has been studied after administration of 3H-thymidine. The results indicate that the dividing fraction of lymphoid cells is more resistant to radiation than the fraction of nondividing lymphocytes. The time courses of the specific activities of DNA in thymus and spleen were different especially after irradiation with lethal doses. It is suggested that the process of depletion in the lymphoid series is probably similar for both thymus and spleen but, the different cellular composition of these organs led to apparently unrelated results.
在给正常和受照射（60Co）小鼠注射3H-胸腺嘧啶核苷后，研究了标记DNA在胸腺和脾脏中的释放及保留过程。结果表明，淋巴细胞的分裂部分比非分裂淋巴细胞部分对辐射更具抗性。胸腺和脾脏中DNA比活性的时间进程不同，尤其是在接受致死剂量照射后。有人认为，胸腺和脾脏中淋巴细胞系列的耗竭过程可能相似，但这些器官不同的细胞组成导致了明显不相关的结果。
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