奥氮平或利培酮稳定治疗的精神分裂症患者的主观体验与纹状体多巴胺D(2)受体占有率
Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone.
作者信息
de Haan L, Lavalaye J, Linszen D, Dingemans P M, Booij J
机构信息
Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands.
出版信息
Am J Psychiatry. 2000 Jun;157(6):1019-20. doi: 10.1176/appi.ajp.157.6.1019.
OBJECTIVE
The authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D(2) receptor occupancy in stabilized patients with schizophrenia.
METHOD
Subjective experience, psychopathology, and extrapyramidal symptoms were assessed, and D(2) receptor occupancy was determined with [(123)I]iodobenzamide single photon emission computed tomography, in 22 patients whose schizophrenia was stabilized by olanzapine or risperidone.
RESULTS
Subjective experience, depression, and negative symptoms were related to dopamine D(2) receptor occupancy, but extrapyramidal symptoms were not.
CONCLUSIONS
These results provide preliminary evidence that negative subjective experience is related to high D(2) receptor occupancy. Longitudinal study is required because this relationship may have implications for dosing strategies.
目的
作者旨在研究奥氮平或利培酮治疗期间稳定期精神分裂症患者的主观体验与多巴胺D(2)受体占有率之间的关系。
方法
对22例使用奥氮平或利培酮病情稳定的精神分裂症患者进行主观体验、精神病理学和锥体外系症状评估，并用[(123)I]碘苄胺单光子发射计算机断层扫描测定D(2)受体占有率。
结果
主观体验、抑郁及阴性症状与多巴胺D(2)受体占有率有关，但锥体外系症状与之无关。
结论
这些结果提供了初步证据，表明负面主观体验与高D(2)受体占有率有关。鉴于这种关系可能对给药策略有影响，因此需要进行纵向研究。
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