用于预防同种异体移植反应的 HLA 相容供体角膜。

HLA-compatible donor cornea for prevention of allograft reaction.

作者信息

Vannas S, Karjalainen K, Ruusuvaara P, Tiilikainen A

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Mar 3;198(3):217-22. doi: 10.1007/BF00410714.

Abstract

Our series comprises 80 penetrating grafts. Of the recipient corneas 36 were vascularized. Of the donor corneas 48 were fresh and 32 were cryopreserved. As prophylaxis, we gave topical and systemic prednisolone, combined, in heavily vascularized cases, with azathioprine. Corneal donor-recipient pairs were divided into three groups according to HLA histocompatibility. In Group I (0-1 mismatch) the rate of allograft reaction was 1 in 27, in Group II (2-4 mismatches) it was 4 in 19, and in the untyped Group III 9 in 34. Even when the prognosis was poor, a well-matched donor cornea (Group I) greatly improved the chances of success; when the corneal bed was vascularized, the well-matched donor corneas had a failure rate of 1 in 13, whereas in untyped pairs it was 7 in 18. The importance of possible presensitization is discussed.

摘要

我们的系列研究包括80例穿透性移植。在接受移植的角膜中，36例有血管化。在供体角膜中，48例是新鲜的，32例是冷冻保存的。作为预防措施，我们给予局部和全身泼尼松龙，在血管化严重的病例中，联合使用硫唑嘌呤。根据HLA组织相容性将角膜供体-受体对分为三组。在第一组（0-1个错配）中，同种异体移植反应率为27例中有1例，在第二组（2-4个错配）中为19例中有4例，在未分型的第三组中为34例中有9例。即使预后较差，匹配良好的供体角膜（第一组）也大大提高了成功的机会；当角膜床有血管化时，匹配良好的供体角膜失败率为13例中有1例，而在未分型的配对中为18例中有7例。文中讨论了可能的预致敏的重要性。