Vannas S, Tiilikainen A, Vannas A, Karjalainen K
Acta Ophthalmol (Copenh). 1978 Oct;56(5):689-96. doi: 10.1111/j.1755-3768.1978.tb06632.x.
Our series comprised 100 penetrating corneal transplantations: 36 cases with HLA-B 12 and/or B 27 antigen in the recipient and, as controls, 64 cases without these antigens. The cornea was vascular in 44% of the HLA-B 12/B 27 group and in 40% of the controls. In the HLA-B 12/B 27 group AR developed in 13 of 36 cases, 36%; but in the control group only in one case (2%). In vascular and avascular cases the incidence of AR was equal. Among the high-risk cases of the HLA-B 12/B 27 group with definite mismatching of B 12 or B 27 antigens, 9 of the 14 recipients had developed AR. Six further recipients of this group had untyped grafts, and AR occurred in 4 of the 6, but in none of the 16 cases that were matched for B 12 or B 27 antigens. The value of a compatible graft, at least to the carriers of HLA-B 12 and/or B 27 antigens, is thus confirmed.
我们的系列研究包括100例穿透性角膜移植手术：36例受者有HLA - B12和/或B27抗原，作为对照，64例受者没有这些抗原。HLA - B12/B27组中44%的角膜有血管，对照组中这一比例为40%。HLA - B12/B27组36例中有13例（36%）发生排斥反应（AR）；但对照组仅1例（2%）发生。在有血管和无血管的病例中，AR的发生率相同。在HLA - B12/B27组中，B12或B27抗原明确不匹配的高危病例中，14例受者中有9例发生了AR。该组另有6例受者接受的是未分型移植物，6例中有4例发生了AR，但在16例B12或B27抗原匹配的病例中无一例发生。因此证实了相容性移植物的价值，至少对于HLA - B12和/或B27抗原携带者是如此。
