van Tongeren M J, Kromhout H, Gardiner K
Institute of Occupational Health, University of Birmingham, B15 2TT, Birmingham, UK.
Ann Occup Hyg. 2000 Jun;44(4):271-80.
In an attempt to investigate the relationship between exposure to carbon black and respiratory morbidity, a study of the complete carbon black manufacturing industry in Western Europe was commissioned. As part of this study, a large number of personal inhalable (n=8015) dust exposure measurements was taken during three phases of data collection between 1987 and 1995. Repeated measurements on the same worker were taken in the last two phases, which enabled the estimation of the within- and between-worker components of variance. Simultaneously, the fixed effects of phase and factory were estimated using mixed-effects analysis of variance. The results show that the personal inhalable dust exposure has reduced significantly since the first phase of the study. In addition, the interaction term between phase and factory was significant in most job categories, confirming that the reduction of exposure was not equal across all factories. When all factories were considered together, the probability that the mean exposure of a randomly selected worker (overexposure) or the probability that the exposure on a randomly selected day for a randomly selected worker (exceedance) was higher than 3.5mg m(-3), was 10% or less for all job categories in the last phase. However, when the factories were considered separately, it appeared that the probability of overexposure or exceedance was in excess of 10% for the job categories 'Fitter/Welder', 'Warehouseman' and 'Site crew' for a number of factories. Therefore, even though exposure levels of inhalable dust have dropped considerably across the whole carbon black manufacturing industry in Western Europe, further reductions in exposure levels are required in these areas to make sure that the probability of overexposure and exceedance falls below a level of 10%.
为了研究接触炭黑与呼吸道疾病之间的关系,委托开展了一项针对西欧炭黑制造业的全面研究。作为这项研究的一部分,在1987年至1995年的数据收集的三个阶段进行了大量个人可吸入(n = 8015)粉尘接触测量。在最后两个阶段对同一工人进行了重复测量,这使得能够估计工人内部和工人之间的方差成分。同时,使用方差混合效应分析估计阶段和工厂的固定效应。结果表明,自研究的第一阶段以来,个人可吸入粉尘接触量已显著降低。此外,阶段和工厂之间的交互项在大多数工作类别中具有显著性,这证实了各工厂的接触量减少并不相同。当将所有工厂综合考虑时,在最后阶段,随机选择的工人平均接触量(过度接触)高于3.5mg m(-3)的概率或随机选择的工人在随机选择的一天的接触量(超标)高于3.5mg m(-3)的概率,在所有工作类别中均为10%或更低。然而,当分别考虑各个工厂时,对于一些工厂的“钳工/焊工”、“仓库管理员”和“现场工作人员”等工作类别,过度接触或超标的概率超过了10%。因此,尽管西欧整个炭黑制造业的可吸入粉尘接触水平已大幅下降,但在这些领域仍需要进一步降低接触水平,以确保过度接触和超标的概率降至10%以下。