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本文引用的文献

1
Assays with first- or second-generation transplants of spontaneous mammary adenocarcinomas of mice.对小鼠自发性乳腺腺癌第一代或第二代移植瘤的检测。
Cancer Res. 1955;Suppl. 3:32-7.
2
THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE.亚叶酸钙延迟给药对甲氨蝶呤免疫抑制作用的影响。
Immunology. 1965 Mar;8(3):251-9.
3
Folic acid antagonists in cancer chemotherapy.癌症化疗中的叶酸拮抗剂。
Pharmacol Rev. 1962 Mar;14:91-135.
4
Chemotherapy and surgery of spontaneous tumors of mice.小鼠自发性肿瘤的化疗与手术
Eur J Cancer (1965). 1966 Feb;2(1):1-7. doi: 10.1016/0014-2964(66)90083-1.
5
The influence of intracellular recovery and hypoxic cells on the radiation response of mammary tumours and skin in C3H mice.细胞内恢复和乏氧细胞对C3H小鼠乳腺肿瘤及皮肤辐射反应的影响。
Br J Radiol. 1969 Mar;42(495):215-23. doi: 10.1259/0007-1285-42-495-215.
6
[The effect of the folic acid antagonists (Methotrexate) on regeneration of the intestinal mucosa].[叶酸拮抗剂（甲氨蝶呤）对肠黏膜再生的影响]
Virchows Arch Pathol Anat Physiol Klin Med. 1966 Jun 21;341(2):164-76.

甲氨蝶呤对雌性C3H小鼠自发性乳腺腺癌的影响。

The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.

作者信息

Shewell J

出版信息

Br J Cancer. 1976 Feb;33(2):210-6. doi: 10.1038/bjc.1976.27.

DOI:10.1038/bjc.1976.27
PMID:1083245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2024931/
Abstract

The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When methotrexate is injected into the tumour a dose-dependent tumour response is obtained. Systemic citrovorum "rescue" prevents methotrexate lethalities but reduces tumour response by a factor of 2. Methotrexate-treated tumours have an increased volume doubling time post treatment.

摘要

已使用雌性C3H/Bts小鼠的自发性乳腺腺癌研究了甲氨蝶呤对实体啮齿动物肿瘤的作用。由于这些肿瘤表现出广泛的体积倍增时间，因此对甲氨蝶呤的肿瘤反应计算必须与倍增时间相关。当将甲氨蝶呤注射到肿瘤中时，可获得剂量依赖性的肿瘤反应。全身性亚叶酸“解救”可防止甲氨蝶呤致死，但会使肿瘤反应降低一半。经甲氨蝶呤治疗的肿瘤在治疗后体积倍增时间增加。