Serio G
Dipartimento di Scienze Chirurgiche e Gastroenterologiche Università di Verona.
Chir Ital. 2000 Jan-Feb;52(1):1-9.
Technological progress and the evolution of biological knowledge lead us to expect major developments in the fields of organ replacement, minimally invasive surgery and tumour therapy in the coming decades. It is widely believed that xenotransplantation may offer a possible solution to the problem of the current chronic shortage of donors, though their use at present encounters formidable immunological obstacles, particularly as regards discordant transplants. Genetic engineering and the realisation of transgenic donors as well as new strategies aimed at modifying the immune status of the donor may well be the key to new developments in this sector. Selective culturing of tissues and the production of totally implantable artificial organs are additional lines of research which may provide useful means of meeting the increasing demand for organs. The enormous advances made in the field of high-tech solutions applied to the biomedical disciplines are destined to open up new frontiers in diagnostics, operating technique and the permanent training of surgeons. In particular, we are about to witness an extension of the use of computer technology and robotics, embracing the simulation and reproduction of virtual reality, telemedicine (teleconsulting and telesurgery) and the creation of experimental models. Minimally invasive surgery will unquestionably benefit from this progress with the possibility of extending its range of indications to procedures in which human limitations are more evident owing to difficulties of access and the size of the target, at the same time guaranteeing high-precision manoeuvres. In the oncological field, high expectations accompany the advances in our knowledge of molecular biology with the genetic mapping of tumours which may pave the way for screening programs and gene therapy. Alongside the scientific and technological development of the surgery of the future, we can expect to see the increasing emergence of: a) economic problems related to the progressive increase in healthcare costs, amongst other things as a result of the powerful impact of high-tech solutions; b) social problems in terms of the inevitable conflict between cost-containment policies and the right to healthcare; c) moral and bioethical problems relating to the possible establishment of genetic registries and to the different patient-care provider relationship which is likely to come about as the result of the interference of machines or robots. The surgeon's persona may undergo profound changes, not merely from the technical and professional training standpoint, but also with regard to his or her effective role, which may no longer be that of a central, dominant figure, but may be scaled down in a context of multidisciplinary co-operation.
技术进步和生物学知识的发展使我们预计,在未来几十年里,器官置换、微创手术和肿瘤治疗领域将取得重大进展。人们普遍认为,异种移植可能为当前供体长期短缺的问题提供一个可能的解决方案,尽管目前其应用面临巨大的免疫障碍,尤其是在非协调性移植方面。基因工程、转基因供体的实现以及旨在改变供体免疫状态的新策略很可能是该领域新进展的关键。组织的选择性培养和完全可植入人工器官的生产是另外的研究方向,它们可能为满足对器官日益增长的需求提供有用的方法。应用于生物医学学科的高科技解决方案领域所取得的巨大进展注定会在诊断、手术技术和外科医生的终身培训方面开辟新的前沿。特别是,我们即将见证计算机技术和机器人技术应用范围的扩大,包括虚拟现实的模拟和再现、远程医疗(远程会诊和远程手术)以及实验模型的创建。微创手术无疑将从这一进展中受益,有可能将其适应证范围扩大到因进入困难和目标大小而使人类局限性更为明显的手术,同时保证高精度操作。在肿瘤学领域,随着我们对分子生物学认识的进步以及肿瘤基因图谱的绘制,人们寄予厚望,这可能为筛查计划和基因治疗铺平道路。除了未来手术的科技发展,我们还可以预期会越来越多地出现以下情况:a)与医疗保健成本逐步上升相关的经济问题,这在一定程度上是高科技解决方案的强大影响所致;b)在成本控制政策与医疗保健权利之间不可避免的冲突方面的社会问题;c)与可能建立基因登记以及由于机器或机器人的介入可能出现的不同医患关系相关的道德和生物伦理问题。外科医生的角色可能会发生深刻变化,不仅从技术和专业培训的角度来看如此,而且就其实际作用而言也是如此,其作用可能不再是核心、主导性的,而是可能在多学科合作的背景下被弱化。