Felip C M, Rodríguez-Arias M, Espejo E F, Miñarro J, Stinus L
Area de Psicobiología, Facultad de Psicología, Universitat de Valencia, Spain.
Behav Neurosci. 2000 Apr;114(2):424-30. doi: 10.1037//0735-7044.114.2.424.
The purpose of this study was to determine whether an environment associated with naloxone-induced morphine withdrawal affects aggressive or social behaviors in postdependent mice. Morphine-dependent or saline-treated mice received 3 naloxone injections in 1 of 2 different environments (A or B); 15 days afterward, when the mice were completely drug free, an aggression test was carried out in Environment A. All the mice suffering morphine withdrawal showed a significant increase in aggression, irrespective of the environment in which the withdrawal took place. In these conditions, the impact of morphine dependence and the 3 induced withdrawals was so profound that the environment could not be discriminative. In addition, modifications in the behavioral profile of postdependent mice that suffered only spontaneous withdrawal were long-lasting, with the mice carrying out more attacks during social investigation without presenting threat postures.
本研究的目的是确定与纳洛酮诱导的吗啡戒断相关的环境是否会影响依赖后小鼠的攻击或社交行为。吗啡依赖或生理盐水处理的小鼠在2种不同环境（A或B）中的1种环境中接受3次纳洛酮注射；15天后，当小鼠完全无药时，在环境A中进行攻击测试。所有经历吗啡戒断的小鼠，无论戒断发生在何种环境中，其攻击性均显著增加。在这些条件下，吗啡依赖和3次诱导戒断的影响非常深刻，以至于环境无法起到区分作用。此外，仅经历自发戒断的依赖后小鼠的行为特征变化是持久的，这些小鼠在社交探究期间进行更多攻击，且不表现出威胁姿势。
